Tsawg-hloov hydroxypropyl cellulose (L-HPC) yog dawb los tawm- cov hmoov dawb, insoluble hauv dej tab sis muaj peev xwm nqus dej sai thiab o 3-5 npaug ntawm nws qhov ntim qub. Nws muaj ob qho tib si disintegrant thiab nplaum cov khoom, yog tshuaj lom neeg ruaj khov, thiab muaj qhov dav siv pH ntau (5.0-7.5).
Lub physicochemical thiab functional zog ntawm L-HPC muab nws tshwj xeeb zoo nyob rau hauv kws tshuaj thiab lwm yam teb. Cov yam ntxwv tshwj xeeb yog raws li nram no:
Lub cev muaj zog
Cov tsos mob: Dawb los yog tawm -dawb hmoov los yog fibrous crystals, tsw thiab saj, nrog zoo flowability.
Particle loj yog adjustable; Cov qauv muaj xws li LH-21 (kwv yees li 40-60 mesh) thiab LH-31 (cov khoom zoo), haum rau cov txheej txheem granulation sib txawv.
Nws muaj qhov ntxeem tau, ntxhib qauv, uas ua rau muaj kev cuam tshuam "kev cuam tshuam" nrog cov khoom siv tshuaj, txhim kho kev sib khi quab yuam.
Solubility thiab o Properties
Nws yog insoluble nyob rau hauv cov kuab tshuaj xws li dej, ethanol, acetone, thiab ether, tab sis nws muaj peev xwm nqus dej sai sai thiab o 3-5 npaug ntawm nws thawj ntim hauv dej, ua kom muaj zog tawg.
Cov qib o yog qhov siab dua li cov hmoov txhuv nplej siab (txog 720% vs 180%), uas yog lub hauv paus txheej txheem ntawm nws cov kev ua tau zoo heev.
Nws tuaj yeem muab faib ua ib feem hauv cov kua dej cawv uas muaj 60% dej, ua rau nws haum rau qee cov txheej txheem ntub dej granulation.
Tshuaj Stability
Cov tshuaj yog ruaj khov nyob rau hauv pH ntau ntawm 5.0-7.5. Cov acidity heev (pH <2) yuav ua rau nag lossis daus, thaum muaj zog alkalinity (pH> 10) yuav txo viscosity.
It is stable to light and heat, but prolonged exposure to high temperatures (>40 degree) tuaj yeem cuam tshuam kev ua haujlwm; pom zoo cia kom deb ntawm lub teeb.
Raws li ib qho tsis yog -ionic cellulose derivative, nws muaj kev sib raug zoo nrog cov tshuaj feem ntau thiab tsis zoo li yuav muaj kev cuam tshuam tsis zoo.
